MAPK13

Description

The MAPK13 (mitogen-activated protein kinase 13) is a protein-coding gene located on chromosome 6.

Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.

== Function == The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.

== References ==

== Further reading ==

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

MAPK13 is a serine/threonine kinase that is a key component of the MAP kinase signal transduction pathway. It is one of four p38 MAPKs, which are involved in cellular responses to stimuli like pro-inflammatory cytokines or physical stress. These kinases activate transcription factors like ELK1 and ATF2 by phosphorylation. p38 MAPKs are known to phosphorylate a wide range of proteins, with estimates suggesting they have around 200-300 substrates each. Although less studied than other p38 MAPK isoforms, MAPK13 plays roles in various cellular processes. It regulates protein translation by inactivating EEF2K through phosphorylation. MAPK13 also contributes to cytoskeletal remodeling by phosphorylating MAPT and STMN1. Additionally, it mediates the upregulation of CXCL14 gene expression in response to UV irradiation. MAPK13 is crucial in regulating epidermal keratinocyte differentiation, apoptosis, and skin tumor development. It phosphorylates MYB, a transcriptional activator, in response to stress, leading to MYB degradation through the proteasome pathway. MAPK13 also phosphorylates and downregulates PRKD1, playing a role in insulin secretion regulation in pancreatic beta cells.

MAPK13 is also known as MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing