MAP4
Description
The MAP4 (microtubule associated protein 4) is a protein-coding gene located on chromosome 3.
MAP4, encoded by the MAP4 gene, is a major non-neuronal microtubule-associated protein. It contains a domain similar to microtubule-binding domains found in neuronal microtubule-associated proteins MAP2 and tau (MAPT/TAU). MAP4 promotes microtubule assembly and counteracts destabilization of interphase microtubules. It interacts with cyclin B, targeting cell division cycle 2 (CDC2) kinase to microtubules. Phosphorylation of MAP4 affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. The ubiquitous isoform, uMAP4, functions in the architecture and positioning of the mitotic spindle. oMAP4, predominantly expressed in brain and muscle, organizes microtubules into antiparallel bundles. mMAP4 is a muscle-specific isoform.
MAP4 is also known as -.
