MAP3K1 : mitogen-activated protein kinase kinase kinase 1
Description
The MAP3K1 (mitogen-activated protein kinase kinase kinase 1) is a protein-coding gene located on chromosome 5.
The MAP3K1 gene provides instructions for making a protein that helps regulate signaling pathways that control various processes in the body, including the processes of determining sex characteristics before birth. The MAP3K1 protein attaches (binds) to other molecules called RHOA, MAP3K4, FRAT1, and AXIN1. The binding of MAP3K1 to these molecules, which are called cofactors, helps MAP3K1 control the activity of the signaling pathways.
MAP3K1 is a component of a protein kinase signal transduction cascade. It activates the ERK and JNK kinase pathways by phosphorylating MAP2K1 and MAP2K4. It may also phosphorylate the MAPK8/JNK1 kinase. Additionally, it activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
MAP3K1 is also known as MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6.
Associated Diseases
- 46,XY partial gonadal dysgenesis
- 46,xy sex reversal 6
- 46,XY complete gonadal dysgenesis
- Breast cancer
- Swyer syndrome
- Langerhans cell histiocytosis
