MAP2K3
Description
The MAP2K3 (mitogen-activated protein kinase kinase 3) is a protein-coding gene located on chromosome 17.
MAP2K3 (Dual specificity mitogen-activated protein kinase kinase 3) is an enzyme encoded by the MAP2K3 gene in humans. It is a dual specificity protein kinase belonging to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and activates MAPK14/p38-MAPK. MAP2K3 can be activated by insulin and is necessary for the expression of glucose transporter. The expression of the RAS oncogene results in the accumulation of the active form of MAP2K3, leading to the constitutive activation of MAPK14 and oncogenic transformation of primary cells. Inhibition of this kinase is involved in the pathogenesis of Yersinia pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
MAP2K3 interacts with TAOK2 and PLCB2.
MAP2K3 is also known as MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2.
