MAP2
Description
The MAP2 (microtubule associated protein 2) is a protein-coding gene located on chromosome 2.
MAP2 is a protein encoded by the MAP2 gene in humans. It belongs to the microtubule-associated protein (MAP) family, which are proteins that bind to microtubules. MAP2 is involved in microtubule assembly, a crucial process for the development of nerve cell extensions called neurites. Four main forms of MAP2 exist: MAP2A, MAP2B, MAP2C, and MAP2D. The larger forms, MAP2A and MAP2B, are involved in stabilizing microtubule growth by linking them to intermediate filaments and other microtubules. These isoforms are specific to neurons and are found primarily in dendrites and the cell body. This suggests a role in defining and maintaining the structure of neurons during development. Antibodies against MAP2 are frequently used in research to identify neuronal cells and trace dendritic pathways.
MAP2 is also known as MAP-2, MAP2A, MAP2B, MAP2C.
Associated Diseases
- Rett syndrome
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failures 50
- spermatogenic failure 25
- spermatogenic failure, X-linked, 2
- spermatogenic failure 61
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 48
- isochromosomy Yp
