MAP1LC3A
Description
The MAP1LC3A (microtubule associated protein 1 light chain 3 alpha) is a protein-coding gene located on chromosome 20.
MAP1LC3A (Microtubule-associated proteins 1A/1B light chain 3A) is a protein encoded by the MAP1LC3A gene in humans. It exists in two isoforms and serves as one of the light chain subunits that can associate with either MAP1A or MAP1B, microtubule-associated proteins involved in cytoskeleton interactions. MAP1LC3A is a mammalian homologue of yeast ATG8 and is a key marker and effector of autophagy. Its activity is regulated by post-translational modifications, including covalent attachment of phosphatidylethanolamine to its C-terminus and phosphorylation by protein kinase A. These modifications influence its autophagy functions. Noncovalent interactions play a crucial role in its cargo targeting in selective autophagy, as exemplified by its interaction with sequestosome 1.
MAP1LC3A, also known as LC3A, is a ubiquitin-like modifier that plays a crucial role in the formation of autophagosomes, which are double-membrane vesicles involved in the degradation of cellular components. LC3A specifically participates in the elongation of the phagophore membrane, a precursor to the autophagosome. While LC3A contributes to the initial stages of autophagosome formation, the GABARAP/GATE-16 subfamily of proteins is essential for later stages of autophagosome maturation. Notably, LC3A interacts with the reticulophagy receptor TEX264, facilitating the remodeling of endoplasmic reticulum subdomains into autophagosomes during nutrient stress. These autophagosomes subsequently fuse with lysosomes, leading to the degradation of the endoplasmic reticulum.
MAP1LC3A is also known as ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3.
