MAP1B
Description
The MAP1B (microtubule associated protein 1B) is a protein-coding gene located on chromosome 5.
MAP1B is a microtubule-associated protein involved in microtubule assembly, a crucial step in neurogenesis. The MAP1B gene produces a precursor protein that undergoes processing to create the final MAP1B heavy chain and LC1 light chain. Studies in mice suggest a significant role for MAP1B in the development and function of the nervous system. Two alternative transcript variants have been reported. MAP1B interacts with Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) and RASSF1.
MAP1B promotes the addition of tyrosine to alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B is essential for proper microtubule dynamics and contributes to the cytoskeletal rearrangements associated with neuronal differentiation and neurite outgrowth. MAP1B likely binds to at least two tubulin subunits within the microtubule polymer, potentially playing a role in initiating microtubule assembly and stabilizing microtubules. MAP1B functions as a positive regulator in DAPK1-mediated autophagic vesicle formation and membrane blebbing.
MAP1B is also known as DFNA83, FUTSCH, MAP5, PPP1R102, PVNH9.
Associated Diseases
- Periventricular nodular heterotopia
- Periventricular nodular heterotopia 9
- Deafness, autosomal dominant 83
