MAN2A2
Description
The MAN2A2 (mannosidase alpha class 2A member 2) is a protein-coding gene located on chromosome 15.
MAN2A2 plays a critical role in the production of complex N-glycans, acting as a catalyst for the initial step in this process. Specifically, it facilitates the conversion of high mannose structures into complex N-glycans, marking the final hydrolytic stage in the N-glycan maturation pathway.
MAN2A2 is also known as MANA2X, alpha-MIIx.
Associated Diseases
- Hirschsprung disease
- partial chromosome Y deletion
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 25
- spermatogenic failures 50
- spermatogenic failure, X-linked, 2
- spermatogenic failure 48
- congenital bilateral absence of vas deferens
- spermatogenic failure 63
- spermatogenic failure 1
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 61
- spermatogenic failure 22
- isochromosomy Yp
- spermatogenic failure 47
- spermatogenic failure 40
- spermatogenic failure, X-linked, 3
- spermatogenic failure 11
