MAN1B1-AS1
Title: man1b1-as1: A Non-Coding RNA with Impactful Roles in Health and Disease
Description:
man1b1-as1 is a long non-coding RNA (lncRNA) that plays critical roles in various biological processes and is linked to several diseases. LncRNAs are non-protein coding RNA molecules that regulate gene expression and have emerged as important regulators of cellular functions. man1b1-as1 is located on chromosome 1q21.3 and is highly conserved across species.
Associated Diseases:
man1b1-as1 has been implicated in a range of diseases, including:
- Cancer: man1b1-as1 overexpression is associated with tumor growth, metastasis, and poor prognosis in several cancers, including breast cancer, lung cancer, and colorectal cancer. It regulates cell cycle progression, apoptosis, and angiogenesis.
- Neurodegenerative diseases: Decreased man1b1-as1 levels are linked to the development and progression of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It modulates neuronal survival and protects against neurotoxicity.
- Cardiovascular diseases: man1b1-as1 is involved in the regulation of cardiac function and inflammation. Dysregulation of man1b1-as1 is associated with abnormal heart development, arrhythmias, and myocardial infarction.
Did you Know ?
In a study of over 500 breast cancer patients, higher man1b1-as1 expression was associated with a 2-fold increased risk of recurrence and a 30% lower survival rate.
