MAGT1 : magnesium transporter 1
Description
The MAGT1 (magnesium transporter 1) is a protein-coding gene located on chromosome X.
The MAGT1 gene produces a protein called a magnesium transporter, which moves magnesium into immune cells called T cells. T cells fight off infections by attacking foreign invaders like viruses and bacteria. The magnesium transporter made by MAGT1 is found in a specific type of T cell (CD8+ T cell) that is important for controlling viral infections. These cells take in magnesium when they detect a foreign invader, which helps them activate their response. Researchers think that magnesium transport might also be involved in making another type of T cell (helper T cell) in the thymus gland. Helper T cells direct and support other immune cells.
MAGT1 protein is a component of the STT3B-containing form of the oligosaccharyltransferase (OST) complex, which adds sugar chains (N-glycosylation) to newly made proteins. MAGT1 specifically helps with the glycosylation of certain sites near cysteine residues in proteins. It can work together with another protein called TUSC3 in this process. MAGT1 can also bind to the protein it is helping to glycosylate in a way that makes it easier for the OST complex to add sugar chains. MAGT1 may also be involved in magnesium transport.
MAGT1 is also known as CDG1CC, IAP, MRX95, OST3B, PRO0756, SLC58A1, XMEN, bA217H1.1.
Associated Diseases
- Immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia
- Congenital disorder of glycosylation, type Icc
- Autoimmune lymphoproliferative syndrome
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia