MAGI2-AS3
MAGI2-AS3: A Comprehensive Guide
Description
MAGI2-AS3 (melanoma antigen family I, 2-antisense RNA 3) is a long non-coding RNA (lncRNA) that plays a crucial role in various biological processes. It is located on chromosome 1p36.33 and is highly conserved across species. MAGI2-AS3 has been implicated in several diseases, including cancer, neurological disorders, and immune system regulation.
Associated Diseases
Cancer:
- Gastric cancer: MAGI2-AS3 promotes gastric cancer cell proliferation, migration, and invasion by regulating the miR-200a/ZEB1 axis.
- Lung cancer: MAGI2-AS3 overexpression is associated with poor prognosis and increased tumor size in lung cancer patients. It promotes tumor growth by activating the Wnt/β-catenin signaling pathway.
- Breast cancer: MAGI2-AS3 inhibits breast cancer cell apoptosis and promotes cell survival by regulating the expression of Bcl-2 and Bax.
Neurological Disorders:
- Alzheimer‘s disease: MAGI2-AS3 is downregulated in the brains of Alzheimer‘s disease patients. It plays a role in neuronal development and synaptic plasticity.
- Parkinson‘s disease: MAGI2-AS3 is implicated in the neuroinflammatory response and neuronal damage in Parkinson‘s disease.
Immune System Regulation:
- Immune cell activation: MAGI2-AS3 regulates the activation and differentiation of immune cells, such as T cells and macrophages.
- Inflammatory diseases: Dysregulation of MAGI2-AS3 expression is associated with the development of inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.
Did you Know ?
In a study of gastric cancer patients, researchers found that elevated MAGI2-AS3 expression was associated with a 57% higher risk of death compared to patients with low MAGI2-AS3 expression.
