MAGEF1
Description
The MAGEF1 (MAGE family member F1) is a protein-coding gene located on chromosome 3.
MAGEF1 enhances the activity of RING-type zinc finger-containing E3 ubiquitin ligases, potentially by recruiting and stabilizing the E2 ubiquitin-conjugating enzyme. This leads to the formation of a complex with NSMCE1, a ubiquitin ligase, which then promotes the degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly machinery. The reduction in MMS19 levels impairs the function of DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1, and POLD1, which rely on iron-sulfur clusters. MAGEF1 may negatively regulate genome integrity by inhibiting homologous recombination-mediated DNA repair.
MAGEF1 is also known as MAGE-F1.
