MAGEC2
Description
The MAGEC2 (MAGE family member C2) is a protein-coding gene located on chromosome X.
MAGEC2 is a protein encoded by the MAGEC2 gene in humans. It belongs to the MAGEC gene family, which is known for its members being expressed in various tumor types, but not in normal tissues except for the testes. The MAGEC genes are located on chromosome Xq26-q27.
MAGEC2 is believed to enhance the activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, which are enzymes responsible for attaching ubiquitin to target proteins. In laboratory settings, MAGEC2 has been shown to increase the activity of the E3 ligase TRIM28, leading to the addition of ubiquitin to p53, a tumor suppressor protein. This ubiquitination ultimately results in the breakdown of p53. MAGEC2 is thought to achieve this by bringing together and/or stabilizing the ubiquitin-conjugating enzymes (E2) with the E3 ligase and the target protein.
MAGEC2 is also known as CT10, HCA587, MAGEE1.
Associated Diseases
- pachyonychia congenita
- cancer
- Miyoshi myopathy
- mucosal melanoma
- gastrointestinal stromal tumor
- Aagenaes syndrome
- classic Hodgkin lymphoma
