MAGEA5
Magea5: An Essential Gene for Cancer Progression
Description
Magea5 is a gene located on the X chromosome that plays a crucial role in cancer cell proliferation, invasion, and metastasis. It encodes a protein that is a member of the MAGE family of tumor-specific antigens. Magea5 is highly expressed in various types of cancer, including lung, breast, prostate, and colon cancer.
Associated Diseases
Overexpression of Magea5 has been linked to several types of cancer, including:
- Lung cancer: Magea5 is one of the most frequently overexpressed genes in lung cancer, with high expression levels correlated with poor prognosis.
- Breast cancer: Magea5 overexpression is associated with aggressive breast cancer subtypes, such as triple-negative breast cancer, and is linked to increased tumor size, lymph node involvement, and distant metastasis.
- Prostate cancer: Magea5 overexpression has been found in prostate cancer cells and is correlated with increased cell proliferation, invasiveness, and resistance to androgen deprivation therapy.
- Colon cancer: Magea5 overexpression is linked to advanced stages of colon cancer and is associated with worse overall survival.
Did you Know ?
According to the Cancer Genome Atlas (TCGA), Magea5 is amplified in approximately 20% of lung cancer cases, making it one of the most commonly amplified genes in this disease.
