MAGEA1
Description
The MAGEA1 (MAGE family member A1) is a protein-coding gene located on chromosome X.
MAGEA1 is a protein encoded by the MAGEA1 gene in humans. It belongs to the MAGEA gene family, whose members share significant sequence similarity. The MAGEA genes are clustered on chromosome Xq28 and have been linked to certain hereditary disorders, such as dyskeratosis congenita. The variability in the promoters and first exons of these genes suggests that they may be regulated by different mechanisms to achieve the same function.
MAGEA1 may regulate gene expression by interacting with SNW1 and recruiting HDAC1, a histone deacetylase. It may also inhibit the activity of Notch intracellular domain (NICD). Additionally, MAGEA1 might play a role in embryonic development and the process of tumor development or progression. It is recognized as an antigen by cytotoxic T lymphocytes in melanoma.
MAGEA1 is also known as CT1.1, MAGE1.
