MAD2L1BP
Description
The MAD2L1BP (MAD2L1 binding protein) is a protein-coding gene located on chromosome 6.
MAD2L1-binding protein is a protein encoded by the MAD2L1BP gene in humans. The protein was identified as a binding protein of MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all kinetochores are attached to the spindle. MAD2L1BP may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Multiple transcript variants encoding distinct isoforms have been observed. MAD2L1BP has been shown to interact with TRIP13.
MAD2L1BP may function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.
MAD2L1BP is also known as CMT2, p31comet.
