LYPD1
Description
The LYPD1 (LY6/PLAUR domain containing 1) is a protein-coding gene located on chromosome 2.
LYPD1 (Ly6/PLAUR domain-containing protein 1) is a protein encoded by the LYPD1 gene in humans. It is also known as Lynx2, a member of the Lynx family of neurotransmitter receptor-binding proteins. Transgenic mice lacking Lynx2 expression exhibit increased anxiety-related behaviors.
LYPD1 is thought to regulate the activity of nicotinic acetylcholine receptors (nAChRs). Studies have shown that LYPD1 increases the rate of receptor desensitization and reduces the affinity of alpha-4:beta-2-containing nAChRs for acetylcholine (ACh). Additionally, LYPD1 may influence the intracellular transport of alpha-4:beta-2 and alpha-7-containing nAChRs, potentially inhibiting their presence on the cell surface. LYPD1‘s role in regulating nAChRs suggests a possible involvement in anxiety control.
LYPD1 is also known as LYPDC1, PHTS.
