LTN1

Description

The LTN1 (listerin E3 ubiquitin protein ligase 1) is a protein-coding gene located on chromosome 21.

Listerin E3 ubiquitin protein ligase 1 (LTN1), otherwise known as listerin, is a protein that in humans is encoded by the LTN1 gene. Like most RING finger proteins, listerin functions as an E3 ubiquitin ligase. Listerin is a component of the ribosome quality control complex.

LTN1, also known as listerin, is an E3 ubiquitin ligase that functions as a component of the ribosome quality control complex (RQC). This complex targets stalled ribosomes and ensures that incompletely synthesized proteins are ubiquitinated and extracted for degradation by the proteasome. LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and directly mediates the ubiquitination of stalled nascent chains. This ubiquitination event then recruits VCP/p97, which extracts and degrades the incomplete translation product.

LTN1 is also known as C21orf10, C21orf98, RNF160, ZNF294.

Associated Diseases

• major depressive disorder
• spinal muscular atrophy, type IV
• familial infantile bilateral striatal necrosis