LTB

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Description

The LTB (lymphotoxin beta) is a protein-coding gene located on chromosome 6.

LTB, or Lymphotoxin beta, is a human protein involved in immune response regulation. It is a cytokine that binds to the LTBR/TNFRSF3 receptor and acts as a membrane anchor for a heterotrimeric complex. While LTB has various meanings, this refers specifically to the human gene and its protein product.

Lymphotoxin-beta (LT-beta) is a cytokine that binds to the LTBR/TNFRSF3 receptor, potentially influencing immune response regulation. It serves as a membrane anchor for the heterotrimeric complex, attaching it to the cell surface. Isoform 2 is likely non-functional.

LTB is also known as TNFC, TNFSF3, TNLG1C, p33.

Associated Diseases

• hyper-IgM syndrome type 2
• hyper-IgM syndrome type 3
• severe combined immunodeficiency due to CD70 deficiency
• immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
• hyper-IgM syndrome type 5
• immunodeficiency 75
• immunodeficiency 72 with autoinflammation
• X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
• immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
• immunodeficiency 78 with autoimmunity and developmental delay
• isolated agammaglobulinemia
• common variable immunodeficiency
• autoimmune lymphoproliferative syndrome type 2B
• T-B+ severe combined immunodeficiency due to JAK3 deficiency
• severe combined immunodeficiency due to LAT deficiency
• hyper-IgM syndrome type 4