LTA4H
Description
The LTA4H (leukotriene A4 hydrolase) is a protein-coding gene located on chromosome 12.
LTA4H is a bifunctional zinc metalloenzyme with both epoxide hydrolase (EH) and aminopeptidase activities. It acts as an EH to convert LTA4 into the pro-inflammatory mediator leukotriene B4 (LTB4). It also exhibits aminopeptidase activity with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its pro-inflammatory EH activity, LTA4H may counteract inflammation by inactivating the tripeptide Pro-Gly-Pro (PGP), a neutrophil attractant, through its aminopeptidase activity. LTA4H is involved in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, which are potent anti-inflammatory and pro-resolving lipid mediators. {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}
LTA4H is also known as -.
