LRRN3
Description
The LRRN3 (leucine rich repeat neuronal 3) is a protein-coding gene located on chromosome 7.
LRRN3, also known as Neuronal leucine-rich repeat protein 3 (NLRR-3), is a protein encoded by the LRRN3 gene in humans. The gene is located on chromosome 7, specifically at 7q31.1, and contains 6 introns. Transcription of the gene results in five different mRNA transcripts, with three main variants encoding the LRRN3 protein. The longest transcript variant is 3744 base pairs long. All three variants have differing lengths and numbers of exons, but they all contain the exon with the complete coding sequence for the LRRN3 protein. The LRRN3 gene has two paralogs, LRRN1 and LRRN2, which share the characteristic leucine-rich repeats of this gene family. The LRRN3 protein is 708 amino acids long and has a molecular weight of 79,424 daltons with an isoelectric point of 8.02. It functions as a single-pass type I membrane protein, spanning the membrane once with its N-terminus on the extracellular side. The signal sequence is removed during protein processing.
LRRN3 is also known as FIGLER5, NLRR-3, NLRR3.
Associated Diseases
- schizophrenia
- Gorham-Stout disease
- diabetes mellitus, transient neonatal, 2
- melorheostosis
- anorexia nervosa
- dacryocystitis-osteopoikilosis syndrome
- 12q14 microdeletion syndrome
- pyknoachondrogenesis
- bipolar disorder
- osteomesopyknosis
