LRRK2


Description

The LRRK2 gene, located on chromosome 12, encodes a large protein called leucine-rich repeat kinase 2. This protein plays a crucial role in various cellular functions, including protein degradation, autophagy, and neuronal signaling. Mutations in the LRRK2 gene are a common cause of familial Parkinson‘s disease, accounting for approximately 5% of cases. However, LRRK2‘s involvement extends beyond Parkinson‘s, with potential links to other neurodegenerative disorders, inflammatory diseases, and even cancer.

Associated Diseases

Did you know?

LRRK2 is one of the largest known human genes, with over 8500 base pairs and encoding a protein containing over 2500 amino acids.


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