LRRC8E
Description
The LRRC8E (leucine rich repeat containing 8 VRAC subunit E) is a protein-coding gene located on chromosome 19.
LRRC8E is a protein encoded by the LRRC8E gene. It is a component of the volume-regulated anion channel (VRAC), which plays a crucial role in regulating cell size by transporting ions and other molecules across the cell membrane. While LRRC8E is not as crucial to VRAC function as LRRC8A and LRRC8D, its presence in the VRAC complex contributes to the diversity of the channel's functions. VRAC is also linked to other cellular processes, such as lysosome homeostasis and immune response. LRRC8E's role in these processes is currently under investigation. A recent study found a possible association between LRRC8E and panic disorder.
LRRC8E is a non-essential subunit of the volume-regulated anion channel (VRAC), which plays a role in maintaining cell volume by transporting chloride ions and other organic molecules across the cell membrane. The VRAC channel is crucial in regulating cell size in response to changes in the environment. LRRC8E is one of several proteins that can form the VRAC channel, and its presence contributes to the diversity of VRAC functions. The channel's activity requires LRRC8A and at least one other member of the LRRC8 protein family. The precise combination of LRRC8 subunits determines the VRAC's specific properties. VRAC is also involved in regulating lysosome homeostasis. It forms functional VRAC channels in lysosomes under specific conditions, helping to control water balance within the cell. The presence of LRRC8E within VRAC complexes may impact the channel's function and specificity.
LRRC8E is also known as -.
