LRRC8B
Description
The LRRC8B (leucine rich repeat containing 8 VRAC subunit B) is a protein-coding gene located on chromosome 1.
Leucine-rich repeat-containing protein 8B (LRRC8B) is a protein encoded by the LRRC8B gene in humans. Along with other LRRC8 proteins (LRRC8A, LRRC8C, LRRC8D, and LRRC8E), LRRC8B can be a subunit of the volume-regulated anion channel (VRAC). VRACs play a vital role in regulating cell size by transporting chloride ions and various organic osmolytes across the cell membrane, including taurine and glutamate. While LRRC8B is one of the proteins that can contribute to VRAC function, research has shown that it is less crucial compared to LRRC8A and LRRC8D. However, while LRRC8A and LRRC8D are essential for VRAC activity, further studies indicate that they are not sufficient for the full range of VRAC functionality. This is where other LRRC8 proteins like LRRC8B come into play, as the specific combination of these subunits influences the VRAC's selectivity. In addition to its role in VRACs, the LRRC8 protein family is also associated with agammaglobulinemia-5.
LRRC8B is a non-essential component of the volume-regulated anion channel (VRAC), which is an anion channel necessary for maintaining a stable cell volume in response to changes in extracellular or intracellular osmotic pressure. VRAC channels preferentially conduct iodide over chloride and can also transport organic osmolytes, like taurine. For proper VRAC function, LRRC8A must be present alongside at least one other member of the LRRC8 protein family (LRRC8B, LRRC8C, LRRC8D, or LRRC8E), and the specific combination of these subunits influences the channel's characteristics.
LRRC8B is also known as TA-LRRP, TALRRP.
