LRRC57
Description
The LRRC57 (leucine rich repeat containing 57) is a protein-coding gene located on chromosome 15.
Leucine rich repeat containing 57, also known as LRRC57 is a protein encoded in humans by the LRRC57 gene.
== Function == The exact function of LRRC57 is not known. It is a member of the leucine-rich repeat family of proteins, which are known to be involved in protein-protein interactions.
== Protein sequence == As is customary for leucine-rich repeat proteins, the sequence is shown below with the repeats starting on their own lines. The beginning of each repeat is a β-strand, which forms a β-sheet along the concave side of the protein. The convex side of the protein is formed by the latter half of each repeat, and may consist of a variety of structures, including α-helices, 310 helices, β-turns, and even short β-strands. Note that the 5' and 3' UTR both are rich in leucines, suggesting that they may be degenerate repeats (the overall protein is 19.7% leucine and 7.5% asparagine, both very rich). The following layout of the LRRC57 amino acid sequence makes it easy to discern the LxxLxLxxNxxL consensus sequence of LRRs.
1 M G N S A L R A H V E T A Q K T G V F Q L K D R G L T E F P A D L Q K L T S N 39 40 L R T I D L S N N K I E S L P P L L I G K F T L 63 64 L K S L S L N N N K L T V L P D E I C N L K K 86 87 L E T L S L N N N H L R E L P S T F G Q L S A 109 110 L K T L S L S G N Q L G A L P P Q L C S L R H 132 133 L D V M D L S K N Q I R S I P D S V G E L Q 154 155 V I E L N L N Q N Q I S Q I S V K I S C C P R 177 178 L K I L R L E E N C L E L S M L P Q S I L S D 200 201 S Q I C L L A V E G N L F E I K K L R E L E G Y D K Y M E R F T A T K K K F A 239 L x x L x L x x N x L x x L x x x x x x L x
== Homology == LRRC57 is exceedingly well conserved, as shown by the following multiple sequence alignment, prepared using ClustalX2. The cyan and yellow highlights call out regions of high conservation and the repeats.
The specific function of LRRC57 is currently unknown. However, being a member of the leucine-rich repeat protein family, it is likely involved in protein-protein interactions.
LRRC57 is also known as -.
