LRRC52
Description
The LRRC52 (leucine rich repeat containing 52) is a protein-coding gene located on chromosome 1.
LRRC52 is an auxiliary protein for the large-conductance, voltage and calcium-activated potassium channel (BK alpha). It modulates the gating properties of BK channels by shifting the voltage dependence of activation towards hyperpolarization, even in the absence of calcium. LRRC52 can also act as an auxiliary protein for KCNU1 channels and may modulate their gating properties.
LRRC52 is also known as -.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 3
- spermatogenic failure 7
- spermatogenic failure 29
- spermatogenic failure 49
- spermatogenic failure 45
- spermatogenic failure 43
- spermatogenic failure 19
- spermatogenic failure 10
- spermatogenic failure 11
- spermatogenic failure 18
- spermatogenic failure 46
- spermatogenic failure 27
- spermatogenic failure 47
- spermatogenic failure 70
- spermatogenic failure 72
- spermatogenic failure 41
- spermatogenic failure 65
- spermatogenic failure, X-linked, 3
