LRIF1
Description
The LRIF1 (ligand dependent nuclear receptor interacting factor 1) is a protein-coding gene located on chromosome 1.
Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1), also known as receptor-interacting factor 1 (RIF1), is a protein encoded by the LRIF1 gene in humans. LRIF1 has been shown to interact with SMCHD1 protein, mutations in which cause facioscapulohumeral muscular dystrophy type 2 (FSHD2). Mutations in LRIF1 itself have also been linked to FSHD2.
LRIF1, in collaboration with SMCHD1, participates in the inactivation of the X chromosome in females by facilitating the condensation of heterochromatin. It also possesses the ability to suppress the transcriptional activity of retinoic acid receptor alpha (RARA) induced by ligand binding, potentially achieved through the direct recruitment of histone deacetylases. Additionally, LRIF1 plays a crucial role in silencing the DUX4 locus within somatic cells.
LRIF1 is also known as C1orf103, FSHD3, HBiX1, RIF1.
