LRG1
Description
The LRG1 (leucine rich alpha-2-glycoprotein 1) is a protein-coding gene located on chromosome 19.
LRG1 is a protein encoded by the LRG1 gene in humans. It plays a role in protein-protein interaction, signal transduction, cell adhesion and development, and is expressed during granulocyte differentiation. LRG1 promotes neovascularization by switching TGFbeta signaling in endothelial cells. It binds to the endoglin receptor and activates the ALK1-Smad1/5/8 pathway. Elevated LRG1 levels are observed in acute appendicitis, making it a potential diagnostic marker. LRG1's role in aberrant neovascularization makes it a potential therapeutic target for various diseases. Increased circulating LRG1 levels are associated with many cancers and could be a useful biomarker. Inhibition of LRG1 can normalize tumor vasculature, improve therapy effectiveness, and limit metastasis. LRG1 has been linked to various diseases, including cancer, eye disease, neurodegenerative disease, diabetes, lung and kidney disease.
LRG1 is also known as HMFT1766, LRG.
Associated Diseases
- allergic disease
- nonpapillary renal cell carcinoma
- ovarian cancer
- cancer
- retinoblastoma
- nail-patella syndrome
