LRFN3
Description
The LRFN3 (leucine rich repeat and fibronectin type III domain containing 3) is a protein-coding gene located on chromosome 19.
LRFN3 acts as a cell adhesion molecule that enables cells to stick to each other without relying on calcium. It promotes the growth of nerve fibers in brain cells called hippocampal neurons.
LRFN3 is also known as FIGLER1, SALM4.
Associated Diseases
- thyroid gland adenocarcinoma
- isolated congenital hypogonadotropic hypogonadism
- 46,XX testicular disorder of sex development
- 46,XY complete gonadal dysgenesis
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
- familial male-limited precocious puberty
- spermatogenic failure, X-linked, 2
- X-linked intellectual disability-macrocephaly-macroorchidism syndrome
- partial chromosome Y deletion
- familial adrenal hypoplasia with absent pituitary luteinizing hormone
- 46,XX ovotesticular disorder of sex development
- spinocerebellar ataxia type 32
- testicular agenesis
- Leydig cell hypoplasia
- partial androgen insensitivity syndrome
- tooth hard tissue disease
