LRCH1
Description
The LRCH1 (leucine rich repeats and calponin homology domain containing 1) is a protein-coding gene located on chromosome 13.
LRCH1 acts as a negative regulator of the GTPase CDC42 by binding to and sequestering its guanine exchange factor, DOCK8. This interaction prevents the activation of CDC42, which in turn negatively regulates the migration of CD4(+) T-cells.
LRCH1 is also known as CHDC1, NP81.
