LPXN
Description
The LPXN (leupaxin) is a protein-coding gene located on chromosome 11.
Leupaxin is a protein encoded by the LPXN gene in humans. It is primarily expressed in hematopoietic cells and is closely related to the focal adhesion protein, paxillin. Leupaxin may participate in cell type-specific signaling by associating with PYK2, a member of the focal adhesion kinase family. It can be a substrate for a tyrosine kinase in lymphoid cells, suggesting a role in tyrosine kinase activity and regulation.
Leupaxin acts as a transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). It plays a role in regulating cell adhesion, spreading, and migration, and acts as a negative regulator in integrin-mediated cell adhesion events. It suppresses integrin-induced tyrosine phosphorylation of paxillin (PXN). Leupaxin may be a critical adapter protein in the formation of the adhesion zone in osteoclasts. It negatively regulates B-cell antigen receptor (BCR) signaling.
LPXN is also known as LDPL.
Associated Diseases
- breast cancer
- isolated agammaglobulinemia
- classic Hodgkin lymphoma
- common variable immunodeficiency
- combined immunodeficiency with skin granulomas
- BENTA disease
- immunodeficiency, common variable, 14
