LPCAT2

Description

The LPCAT2 (lysophosphatidylcholine acyltransferase 2) is a protein-coding gene located on chromosome 16.

Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2, LPCAT-2, LysoPC acyltransferase 2) also know as 1-acylglycerol-3-phosphate O-acyltransferase 11, 1-acylglycerophosphocholine O-acyltransferase, 1-alkenylglycerophosphocholine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, Acetyl-CoA:lyso-platelet-activating factor acetyltransferase, Acyltransferase-like 1, Lysophosphatidic acid acyltransferase alpha. Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198).

LPCAT2 exhibits both acyltransferase and acetyltransferase activities. It catalyzes the conversion of lysophosphatidylcholine (LPC) into phosphatidylcholine (PC), and also converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA). LPCAT2 is involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, lyso-PAF, into PAF. Under resting conditions, acyltransferase activity is preferred, while upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. LPCAT2 is also involved in the regulation of lipid droplet number and size.

LPCAT2 is also known as AGPAT11, AYTL1, LPLAT9, LysoPAFAT.

Associated Diseases

WES Whole Exome Sequencing