LPCAT1

Description

The LPCAT1 (lysophosphatidylcholine acyltransferase 1) is a protein-coding gene located on chromosome 5.

Lysophosphatidylcholine acyltransferase 1 is a protein in humans that is encoded by the LPCAT1 gene. Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis.

LPCAT1 exhibits acyltransferase and acetyltransferase activity, independent of calcium. It catalyzes the conversion of lysophosphatidylcholine (LPC) to phosphatidylcholine (PC) and lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPCAT1 preferentially uses saturated fatty acyl-CoAs as acyl donors and 1-myristoyl or 1-palmitoyl LPC as acyl acceptors. It plays a role in platelet-activating factor (PAF) biosynthesis by converting lyso-PAF to PAF. Additionally, LPCAT1 may synthesize phosphatidylcholine in pulmonary surfactant, contributing to respiratory physiology. It also participates in the regulation of lipid droplet number and size.

LPCAT1 is also known as AGPAT10, AGPAT9, AYTL2, LPCAT-1, LPLAT8, PFAAP3, lpcat, lysoPAFAT.

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