LPAR4
Description
The LPAR4 (lysophosphatidic acid receptor 4) is a protein-coding gene located on chromosome X.
Lysophosphatidic acid receptor 4, also known as LPA4, is a protein encoded by the LPAR4 gene in humans. LPA4 is a G protein-coupled receptor that binds to the lipid signaling molecule lysophosphatidic acid (LPA). LPA4 is related to other receptors, such as lysophospholipid receptors and P2Y receptors.
LPA4 acts as a receptor for lysophosphatidic acid (LPA), a molecule that influences various cellular activities. Upon binding LPA, LPA4 triggers intracellular signaling pathways. These pathways involve increasing calcium levels within the cell and activating adenylyl cyclase, an enzyme that produces cyclic AMP. The effectiveness of different LPA molecules in activating LPA4 follows this order: 1-oleoyl-LPA is the most potent, followed by 1-stearoyl-LPA, 1-palmitoyl-LPA, 1-myristoyl-LPA, 1-alkyl-LPA, and lastly 1-alkenyl-LPA.
LPAR4 is also known as GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9.
Associated Diseases
- ovarian cancer
- thyroid gland adenocarcinoma
- low grade glioma
- pentosuria
- uridine-cytidineuria
- isolated sedoheptulokinase deficiency
- medullary sponge kidney
- Dent disease
- congenital lipoid adrenal hyperplasia due to STAR deficency
- hypophosphatemic nephrolithiasis/osteoporosis 1
- renal hypomagnesemia 2
