LPAR2
LPAR2: A Critical Lipid Receptor with Implications for Disease and Beyond
Description
Lysophosphatidic acid receptor 2 (LPAR2) is a G protein-coupled receptor that binds lysophosphatidic acid (LPA), a lipid mediator involved in various cellular processes, including cell growth, migration, differentiation, and inflammation. LPAR2 is widely expressed throughout the body, particularly in the central nervous system, immune cells, and vascular tissues.
Associated Diseases
Dysregulation of LPAR2 signaling has been implicated in the pathogenesis of several diseases, including:
- Neurological disorders: Schizophrenia, Alzheimer's disease, and multiple sclerosis
- Cardiovascular diseases: Atherosclerosis, hypertension, and heart failure
- Cancer: Melanoma, breast cancer, and colorectal cancer
- Immune disorders: Inflammatory bowel disease, rheumatoid arthritis, and asthma
- Respiratory diseases: Idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease
Did you Know ?
According to a recent study, LPAR2 expression is significantly increased in the brains of individuals with schizophrenia compared to healthy controls. This suggests that LPAR2 may play a role in the pathophysiology of this complex neuropsychiatric disorder.
