LOXL4
Description
The LOXL4 (lysyl oxidase like 4) is a protein-coding gene located on chromosome 10.
LOXL4 is a member of the lysyl oxidase gene family. This family plays a crucial role in connective tissue formation, with the prototypic member encoding an enzyme that catalyzes the first step in collagen and elastin crosslinking. While the C-terminus of LOXL4 shares a conserved sequence responsible for amine oxidase activity, the N-terminus exhibits less conservation and may contribute to additional functions, such as developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis.
LOXL4 is also known as LOXC.
Associated Diseases
- endometrial cancer
- cancer
- schizophrenia 15
- isolated asymptomatic elevation of creatine phosphokinase
- Phelan-McDermid syndrome
- pentosuria
