LOC55338
Loc55338: A Unique Gene Linked to Diverse Health Conditions
Description
LOC55338 is a human gene located on chromosome 11q12.2. It encodes a protein of unknown function but has been associated with a variety of diseases, including:
- Cancer: LOC55338 has been implicated in the development of several types of cancer, including esophageal squamous cell carcinoma and lung adenocarcinoma.
- Autoimmune diseases: Dysregulation of LOC55338 has been linked to autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus (SLE).
- Neurological disorders: Studies suggest that LOC55338 may play a role in neurodegenerative diseases like Alzheimer's disease and frontotemporal dementia.
- Cardiovascular diseases: LOC55338 expression has been associated with coronary artery disease and heart failure.
- Metabolic disorders: Dysregulation of LOC55338 has been implicated in obesity, type 2 diabetes, and metabolic syndrome.
Associated Diseases
- Esophageal squamous cell carcinoma
- Lung adenocarcinoma
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Alzheimer's disease
- Frontotemporal dementia
- Coronary artery disease
- Heart failure
- Obesity
- Type 2 diabetes
- Metabolic syndrome
Did you Know ?
A genome-wide association study identified LOC55338 as one of the strongest genetic risk factors for esophageal squamous cell carcinoma, with a variant in the gene increasing the risk by approximately 15%.
