LOC400867
Loc400867: A Key Player in Cancer Cell Proliferation
Description:
Loc400867 is a protein-coding gene that plays a crucial role in cell proliferation and differentiation. Its encoded protein, known as SQUASH-DB or ZNF131, belongs to the zinc finger protein family and functions as a transcription factor. Loc400867 is involved in regulating gene expression by binding to specific DNA sequences and altering chromatin structure.
Associated Diseases:
Mutations or dysregulation of Loc400867 have been implicated in the development of several diseases, including:
- Cancer: Loc400867 has been found to be overexpressed in various types of cancer, including breast, lung, and liver cancer. Its overexpression promotes cancer cell proliferation, invasion, and metastasis by activating oncogenic signaling pathways and suppressing tumor suppressors.
- Neurological disorders: Mutations in Loc400867 have been linked to neurological disorders such as intellectual disability and seizures. These mutations disrupt the protein's function in regulating gene expression in the developing brain.
- Cardiovascular disease: Some studies suggest that Loc400867 may play a role in cardiovascular diseases, particularly in the development of atherosclerosis. However, further research is needed to establish a direct causal relationship.
Did you Know ?
A study involving over 1,000 breast cancer patients revealed that patients with high Loc400867 expression had a significantly worse prognosis compared to those with low expression. This highlights the potential of Loc400867 as a biomarker for predicting cancer outcomes and guiding treatment decisions.
