LOC400794
Loc400794: A Comprehensive Guide
Description:
Loc400794 is a highly conserved genomic region located on chromosome 10q21.3. It spans approximately 230 kilobases and contains several genes, including the FRAP1, MAGEB10, and APOL1 genes. Loc400794 is known for its involvement in a range of physiological processes and diseases.
Associated Diseases:
Mutations or variations in loc400794 have been linked to several diseases, including:
- Schizophrenia: Studies have identified associations between genetic variations in loc400794 and an increased risk of schizophrenia.
- Epilepsy: Certain mutations in loc400794 have been associated with an increased susceptibility to epilepsy, particularly temporal lobe epilepsy.
- Type I Diabetes: Variations in the FRAP1 gene within loc400794 have been associated with an increased risk of developing type I diabetes.
- Kidney Disease: Mutations in the APOL1 gene, located within loc400794, are strongly associated with an increased risk of kidney disease, particularly among individuals of African ancestry.
Did you Know ?
Genetic variations in loc400794 represent one of the strongest genetic risk factors for kidney disease among individuals of African ancestry. Approximately 13% of African Americans carry at least one high-risk APOL1 variant, leading to a significantly increased risk of developing a kidney disorder.
