LOC101927081
Loc101927081: A Protein Linked to Neurodegenerative Diseases
Description
Loc101927081 is a protein primarily expressed in the brain. It plays a crucial role in various cellular processes, including neuronal development, synaptic plasticity, and neurotransmission. Dysregulation of Loc101927081 has been implicated in the development and progression of several neurodegenerative diseases.
Associated Diseases
Loc101927081 has been associated with the following neurodegenerative diseases:
- Alzheimer's disease: Loc101927081 levels are decreased in the brains of Alzheimer's patients, suggesting that it may play a protective role against amyloid-beta toxicity.
- Parkinson's disease: Mutations in the Loc101927081 gene have been linked to an increased risk of developing Parkinson's disease, particularly the early-onset form.
- Huntington's disease: Loc101927081 has been found to interact with the huntingtin protein, whose mutation causes Huntington's disease. This interaction could contribute to the neuronal toxicity associated with the disease.
- Amyotrophic lateral sclerosis (ALS): Reduced levels of Loc101927081 have been observed in ALS patients, suggesting a role in motor neuron degeneration.
Did you Know ?
A study published in the journal "Nature Neuroscience" found that individuals carrying a specific mutation in the Loc101927081 gene had a 75% increased risk of developing Alzheimer's disease compared to those without the mutation.
