LMTK2
Description
The LMTK2 (lemur tyrosine kinase 2) is a protein-coding gene located on chromosome 7.
LMTK2, also known as Lemur tyrosine kinase 2 (LMTK2), is an enzyme that in humans is encoded by the LMTK2 gene. It belongs to both the protein kinase and the tyrosine kinase families. LMTK2 contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine kinase activity. It interacts with several other proteins, such as androgen receptor, inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. LMTK2 phosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. LMTK2 is involved in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. Loss of LMTK2 has been implicated to play a role in development of prostate cancer. LMTK2 has been shown to interact with PPP1CA, Cyclin-dependent kinase 5 and PPP1R2.
LMTK2 phosphorylates several proteins, including PPP1C (protein phosphatase 1 catalytic subunit alpha), phosphorylase b (an enzyme involved in glycogen metabolism), and CFTR (cystic fibrosis transmembrane conductance regulator).
LMTK2 is also known as AATYK2, BREK, KPI-2, KPI2, LMR2, PPP1R100, cprk, hBREK.
Associated Diseases
- type 2 diabetes mellitus
- cancer
- prostate cancer
- partial chromosome Y deletion
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failures 50
- spermatogenic failure 25
- spermatogenic failure, X-linked, 2
- congenital bilateral absence of vas deferens
- spermatogenic failure 61
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 48
- isochromosomy Yp
- spinocerebellar ataxia type 32
