LMO4
Description
The LMO4 (LIM domain only 4) is a protein-coding gene located on chromosome 1.
LMO4 (LIM domain only 4) is a protein encoded by the LMO4 gene in humans. It contains two LIM domains, cysteine-rich regions, and may function as a transcriptional regulator or an oncogene. LMO4's mRNA has a GC-rich 5' region and multiple ATTT motifs in the 3' region. A variant transcript with a missing 5' portion has been identified, but its confirmation is difficult due to the GC-rich nature of the region. LMO4 has been shown to interact with LDB1, RBBP8, and BRCA1.
LMO4 acts as a transcription cofactor, crucial in establishing motor neuron identity. Collaborating with MNX1, LMO4 disrupts complexes formed by LDB1 and LHX3, leading to the suppression of interneuron gene expression in motor neurons.
LMO4 is also known as -.
