LINC00959
Linc00959: An Emerging Non-Coding RNA with Diverse Roles in Disease
Description
Linc00959 is a long non-coding RNA (lncRNA) that has gained increasing attention in recent years due to its involvement in a wide range of biological processes and diseases. LncRNAs are regulatory RNAs that are longer than 200 nucleotides but do not code for proteins. Linc00959 is located on chromosome 1p36.22 and spans approximately 1,200 nucleotides.
Associated Diseases
Linc00959 has been implicated in several diseases, including:
- Cancer: Linc00959 is overexpressed in various cancers, including breast cancer, lung cancer, and gastric cancer. It promotes cancer cell proliferation, invasion, and metastasis by regulating key molecular pathways.
- Cardiovascular disease: Linc00959 is associated with increased risk of coronary artery disease and heart failure. It modulates the inflammatory response and endothelial function, contributing to cardiovascular dysfunction.
- Neurological disorders: Linc00959 is involved in regulating neuronal differentiation and synaptic plasticity. Its dysregulation is linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
- Immune disorders: Linc00959 influences immune cell function and is associated with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
Did you Know ?
A study published in the journal "Nature Communications" found that increased expression of linc00959 in breast cancer patients was significantly associated with a poorer prognosis. Patients with high linc00959 levels had a 30% higher risk of recurrence and a 25% higher risk of death from breast cancer.
