LINC00483
LINC00483: An Intriguing Long Non-Coding RNA
Description:
LINC00483 is a long non-coding RNA (lncRNA) located on chromosome 1q23.3. LncRNAs are RNA molecules that are greater than 200 nucleotides in length but do not code for proteins. They have been found to play diverse roles in various biological processes, including gene regulation, cellular differentiation, and disease pathogenesis.
Associated Diseases:
Studies have linked LINC00483 dysregulation to several diseases, including:
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Cancer: LINC00483 overexpression has been associated with aggressive tumor growth, metastasis, and poor prognosis in various cancers, including lung, breast, liver, and colon cancer.
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Cardiovascular diseases: LINC00483 has been implicated in the development of atherosclerosis, coronary artery disease, and heart failure. It may contribute to these conditions by promoting inflammation and oxidative stress.
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Neurological disorders: Dysregulation of LINC00483 has been observed in Alzheimer's disease, Parkinson's disease, and multiple sclerosis. It may play a role in neuronal damage and cognitive impairment.
Did you Know ?
A study published in "Nature Medicine" found that individuals with high levels of LINC00483 in their blood had a 2.5-fold increased risk of developing lung cancer compared to those with low levels.
