LINC00403
linc00403: A Novel Long Non-Coding RNA with Intriguing Implications in Cancer and Beyond
Description
linc00403 is a long non-coding RNA (lncRNA) that plays a crucial role in regulating gene expression. It is transcribed from the human chromosome 14 and consists of 2,401 nucleotides. LncRNAs, unlike protein-coding genes, do not encode proteins. Instead, they function as regulatory molecules involved in various cellular processes, including transcriptional and translational regulation, chromatin remodeling, and subcellular localization of proteins.
Associated Diseases
Recent research has implicated linc00403 in the development and progression of several human diseases, particularly cancer. It has been associated with:
- Hepatocellular carcinoma (HCC): Elevated levels of linc00403 have been found in HCC tissues and are correlated with poor patient prognosis. It promotes tumor cell proliferation, migration, and invasion by regulating the expression of key genes involved in these processes.
- Gastric cancer: Lnc00403 is overexpressed in gastric cancer and contributes to tumorigenesis by activating the Wnt/β-catenin signaling pathway, which plays a crucial role in cell growth and differentiation.
- Breast cancer: Studies have shown that linc00403 is upregulated in breast cancer and promotes tumor growth and metastasis by modulating the expression of genes associated with cell cycle progression and angiogenesis.
Did you Know ?
According to a study published in 2021, patients with HCC with high levels of linc00403 had a significantly shorter overall survival rate compared to those with low levels. This finding highlights the potential of linc00403 as a prognostic biomarker for HCC and other cancers.
