LIMK2
Description
The LIMK2 (LIM domain kinase 2) is a protein-coding gene located on chromosome 22.
LIM domain kinase 2 is an enzyme encoded by the LIMK2 gene in humans. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers, commonly found in eukaryotic proteins. These domains likely mediate protein-protein interactions. LIM kinase-1 and LIM kinase-2 are part of a subfamily with unique N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK2 is activated by phosphorylation through ROCK, a Rho effector protein, and subsequently phosphorylates cofilin, inhibiting its actin-depolymerizing activity. This pathway likely contributes to Rho-induced actin cytoskeleton reorganization. Multiple transcript variants encoding different isoforms have been identified for this gene.
LIMK2 is a serine/threonine-protein kinase that plays a critical role in regulating actin filament dynamics. It acts downstream of several Rho family GTPase signal transduction pathways. LIMK2 is involved in astral microtubule organization and mitotic spindle orientation during the early stages of mitosis by phosphorylating TPPP. It can phosphorylate myelin basic protein and histone (MBP) in vitro. LIMK2 suppresses ciliogenesis through various mechanisms, including CFL1 phosphorylation, inhibiting the directional transport of ciliary vesicles to the ciliary base, and promoting YAP1 nuclear localization, where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1.
LIMK2 is also known as -.
