LIMD2
The LIMD2 (LIM Domain Containing 2) gene encodes a protein that plays a significant role in cellular processes such as cell adhesion, migration, and signal transduction. LIM domains are protein-protein interaction domains found in a variety of proteins involved in developmental processes and cytoskeletal organization.
Key Points about LIMD2:
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Location and Structure: The LIMD2 gene is located on chromosome 2q14.2 in humans. The gene encodes a protein that contains a LIM domain, which is involved in mediating protein-protein interactions.
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Function: LIMD2 is implicated in cell motility and the metastatic potential of cancer cells. It is believed to be involved in the regulation of cellular adhesion and migration by interacting with other proteins and signaling pathways.
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Expression: LIMD2 is expressed in various tissues, with higher expression levels observed in certain types of cancer cells. Its expression pattern suggests a role in both normal physiological processes and pathological conditions, particularly in cancer progression.
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Clinical Relevance: Elevated levels of LIMD2 have been associated with increased metastatic potential in certain cancers, making it a potential biomarker for cancer progression and a target for therapeutic intervention. Studies have suggested that LIMD2 expression correlates with poor prognosis in some cancer types.
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Research and Studies: Research on LIMD2 focuses on understanding its role in cancer metastasis and its potential as a therapeutic target. Investigations into its interactions with other proteins and signaling pathways are crucial for uncovering its mechanisms of action.
