LIMA1
Description
The LIMA1 (LIM domain and actin binding 1) is a protein-coding gene located on chromosome 12.
LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.
LIMA1, also known as Epithelial protein lost in neoplasm, is an actin-binding protein involved in regulating the dynamics of the actin cytoskeleton. It increases the number and size of actin stress fibers, inhibits membrane ruffling, and inhibits actin filament depolymerization. It also bundles actin filaments, delays filament nucleation, and reduces the formation of branched filaments. LIMA1 plays a role in cholesterol homeostasis, influencing plasma cholesterol levels by regulating intestinal cholesterol absorption. It may act as a scaffold protein, facilitating cholesterol uptake by regulating the transport of NPC1L1, an essential protein for cholesterol absorption, to the plasma membrane. This regulation is achieved by recruiting MYO5B to NPC1L1.
LIMA1 is also known as EPLIN, LDLCQ8, SREBP3.
