LHX6
Description
The LHX6 (LIM homeobox 6) is a protein-coding gene located on chromosome 9.
The LHX6 gene encodes the LIM/homeobox protein Lhx6, a member of a protein family characterized by the LIM domain, a unique zinc-binding domain. This protein potentially acts as a transcriptional regulator, playing a role in the differentiation and development of neural and lymphoid cells. Two distinct isoforms have been identified due to alternative splicing, although the biological significance of these isoforms is yet to be fully determined.
LHX6 is a probable transcription factor that plays a crucial role in regulating the expression of genes involved in interneuron migration and development. Specifically, it contributes to the differentiation of specific types of cortical interneurons and guides the movement of GABAergic interneuron precursors from the subpallium to the cerebral cortex.
LHX6 is also known as LHX6.1, hLHX6.
Associated Diseases
- multiple sclerosis
- Parkinson disease
- Alzheimer disease
- lysosomal storage disease
- juvenile myoclonic epilepsy
- autosomal dominant epilepsy with auditory features
- developmental and epileptic encephalopathy, 9
- schizophrenia
- benign familial infantile epilepsy
- generalized epilepsy with febrile seizures plus, type 2
- isolated focal cortical dysplasia
- cancer
- Dravet syndrome
