LGI2

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Description

The LGI2 (leucine rich repeat LGI family member 2) is a protein-coding gene located on chromosome 4.

The LGI2 gene in humans encodes for the Leucine-rich repeat LGI family member 2 protein.

LGI2 plays a crucial role in the formation of inhibitory synapses between parvalbumin-positive basket cells and neuronal cell bodies (somas). These synapses are essential for proper neuronal communication and brain function.

LGI2 is also known as LGIL2.

Associated Diseases

• COVID-19
• autosomal dominant epilepsy with auditory features
• Friedreich ataxia
• type 1 diabetes mellitus
• cancer